Kazenga LuaLaua and Ovie Ejaria could return to action against Millwall, but Paddy McNair has been ruled out for two to three weeks.
The midfielder picked up a groin injury during Saturday’s 3-3 draw with Middlesbrough, and was subsequently forced off after just 41 minutes.
LuaLaua and Ejaria, meanwhile, are pushing to face the Lions at the Den on Saturday, but Robbin Ruiter and Marc Wilson remain unavailable.
Speaking to safc.com, Chris Coleman provided the latest news from the treatment room.
“We’ll probably lose Paddy for two or three weeks with his groin which is unfortunate,” revealed the boss.
“Paddy has that physicality in midfield – he has energy and he’s a very good player – so to lose him, especially in the Championship where that type of player can change your life, is a blow.”
He continued: “They [Ejaria and LuaLua] have a really good chance.
“It’s hard because there’s a foot of snow outside so we’ve had to train indoors which is not ideal, as that surface is not really suitable for a lot of our boys.
“Apparently tomorrow isn’t going to be any better, but we think Kaz and Ovie have a really good chance for the weekend.
“Let’s keep our fingers crossed.”