We take a look at three key men for tonight's opponents.
West Ham striker Andy Carroll made his return to action at the start of 2014 after a long-term injury which had kept him on the sidelines since last summer.
The 25-year-old has made eight Barclays Premier League appearances this campaign and could be in line to make his first appearance at the Stadium of Light since being part of the Liverpool side that lost 1-0 to the Black Cats in March 2012.
Carroll moved to the Boleyn Ground in 2012 on a season-long loan before turning the move into a permanent deal last summer. He has scored eight goals in 35 appearances for the Hammers.
Tough-tackling Senegalese midfielder Mohamed Diame has become a vital part of the West Ham side since joining from Wigan in the summer of 2012.
French-born Diame started his career with RC Lens as a teenager before moving to Spain for a spell with Linares in 2007.
After impressive performances he earned a move to then second tier side Rayo Vallecano before joining Wigan Athletic a season later for a fee around £3m.
Diame made 103 appearances during his time with the Latics, scoring seven times, his first coming against Sunderland at the Stadium of Light in a 1-1 draw back in February 2010, Kenwyne Jones scoring for the Black Cats.
The midfielder made a habit of scoring at the Stadium of Light, also finding the back of the net in a 4-2 defeat for the Latics on Wearside; a Jordan Henderson double helping the Black Cats on their way to victory.
The midfielder moved to the Boleyn Ground on a free transfer in June 2012 and has since made 68 appearances for United, scoring six times.
Spanish goalkeeper Adrian has turned heads with his impressive performances since winning the number one shirt at the Boleyn Ground.
Andalusian-born Adrian started his career with Real Betis, predominantly featuring for the B side before making his first-team breakthrough in 2012, that season he would make 31 appearances which included a clean sheet in a win over Real Madrid.
He joined the Hammers on a free transfer in June 2013, and after displacing Jussi Jaaskelainen he has gone on to make 19 appearances for United, keeping six clean sheets in all competitions.