We profile a selection of players who've represented both clubs.
Trinidad and Tobago international Dwight Yorke joined Manchester United from Aston Villa after a nine-year stay at Villa Park where he played over 200 times.
He was part of one of the most successful sides in football history when the Red Devils won the treble in 1999.
Yorke scored 64 times in 188 games in a three-year spell at Old Trafford, during which he struck up a prolific partnership with Andy Cole.
He joined Sunderland in 2006 after spells with Blackburn Rovers, Birmingham City and Sydney FC.
Yorke scored six times in 58 league games on Wearside and was deployed into a defensive midfield role under his former team-mate Roy Keane.
Northern Irish defender Jonny Evans progressed through the youth ranks at United and has made 147 appearances for the Red Devils.
He made his debut for United in September 2007 after spending a season at the Stadium of Light under former Red Devil Roy Keane.
In his first campaign on Wearside he was part of Keane’s promotion-winning side and won the club’s Young Player of the Year award.
He then returned to Old Trafford but only made a handful of appearances before re-joining Sunderland in 2008 and once again proving a key player as the Black Cats retained their top-flight status.
Another product of the United youth setup, Campbell played four times for Sir Alex Ferguson’s side before joining Sunderland in 2009.
He spent time on loan at Royal Antwerp, Hull City and Tottenham Hotspur before Steve Bruce brought him to the Stadium of Light.
Campbell, who has been capped once by England, was prolific in his time with the Tigers, catching the eye of multiple top flight clubs.
Injuries affecting his stay on Wearside limiting his appearances to 72 over four years, with 10 goals.
Campbell moved on to Cardiff City in January 2013.