Chief Executive Steve Walton and Marketing and Commercial Director Lesley Callaghan will step down after 3 and 19 years respectively.
Following the change of ownership in 2009 both directors agreed to remain at the Club for a further 2 years to continue the development of the business and consolidation of the football club in the Premier League.
Chairman Niall Quinn said: "I am deeply indebted to Steve and Lesley for the huge support they have given me during my time at the club. Their professionalism and commitment has helped us to take great strides both on and off the pitch.
"The club is in a far stronger position these days and that is in no small part due to the contribution of both Steve and Lesley. We will be very sorry to see them go."
Steve Walton said: "It has been an honour and a privilege to be the chief executive of the club I have supported all my life. I am particularly proud of the progress we have made over the last 3 years, not just in football terms but the business and its people as a whole.
"I am leaving behind a team of outstanding individuals who I have seen grow in stature and I am confident the foundations are firmly in place for a bright future for all associated with the club."
Lesley Callaghan said "Sunderland is unrecognisable from the football club I joined in 1992 and it has been an amazing journey, which I wouldn't have missed for the world. I am happy to be able to leave the club in such a position in both commercial and football terms.
"I would like to express my deep gratitude to the exceptional professionals that I have had the great pleasure to work with, both past and present, and to wish them and the club even greater success in the future."
