Black Cats defeated at White Hart Lane.
Sunderland suffered defeat in the capital as Spurs erased an early deficit to take the points at White Hart Lane.
The Black Cats took the lead through Lee Cattermole's first goal in a Sunderland shirt – the midfielder scoring from long range after catching Spurs keeper Hugo Lloris out of position.
But Emmanuel Adebayor got the home side back in the contest when he equalised in somewhat fortuitous circumstances just before the half-hour - Wes Brown's clearance appearing to deflect in off the striker.
And youngster Harry Kane tapped the hosts into the lead with the 60-minute mark approaching, turning in a cross from close range.
Christian Eriksen added a third goal 12 minutes from time, finding the corner of the net from just outside the box before Adebayor and sub Gylfi Sigurdsson struck late on.
Having been level at the break, Sunderland were in with a chance of taking something but were ultimately undone by Kane's goal, which preceded the late treble as the hosts pulled away.
Head coach Gus Poyet had made two changes to his side ahead of the game, handing Carlos Cuellar a start ahead of John O'Shea.
Meanwhile Adam Johnson was restored to the starting eleven having scored against West Ham, with Connor Wickham dropping out to accommodate the former Manchester City man.
Johnson slotted in up front alongside Fabio Borini against a Spurs side featuring ex-Sunderland loanee Danny Rose.
Sunderland keeper Vito Mannone had to be alert early on, tipping the ball acrobatically over the bar six minutes in after Eriksen's delivery took a deflection off Marcos Alonso and looped goalwards.
The visitors responded with a great chance just before the quarter-hour. Johnson's free-kick was measured perfectly to the back post, where captain Brown thumped a header just past the far upright with home keeper Lloris motionless.
And Poyet's men then stunned White Hart Lane by taking the lead shortly afterwards.
Defender Vlad Chiriches misdirected a crossfield pass after receiving the ball near the touchline, and Cattermole seized possession before cashing in to beat Lloris from distance as the out-of-position keeper raced across to try and recover the ground.
It was a superb finish from the midfielder, who opened his goalscoring account for the Black Cats.
Spurs responded and Mannone came up with a great save to deny Kane from close range just two minutes after the opening goal.
Meanwhile Kyle Naughton and Adebayor both fired off-target, while Borini forced a good save from Lloris at the other end after holding off Chiriches and teaming up well with Cattermole.
But just as Sunderland looked to be cementing their foothold, the hosts broke through as Adebayor stole in to turn home Eriksen's cross via the unlucky Brown, who was attempting to get a challenge in.
The visitors had some defending to do as Mannone again denied Kane – this time after the youngster shot from a narrow angle – while Rose curled wide from the left-hand edge of the box.
Sunderland were having to deal with significant pressure, with Mannone dropping gratefully on Eriksen's dangerous low ball across the box 10 minutes before the break.
But they held out to go in level at half time and started the second period brightly with Johnson firing over the bar. However, Spurs gradually turned the screw and only a fine sliding clearance from Phil Bardsley prevented Eriksen from tucking home Aaron Lennon's cross.
Tim Sherwood's side then took advantage of another delivery into the box to take the lead just before the hour through Kane, who nipped in front of Brown to tap the ball beyond Mannone.
Sunderland had to go for it and Borini saw a low drive saved by Lloris before Poyet withdrew defender Cuellar for Craig Gardner 18 minutes from time, with Nacho Scocco replacing Cattermole.
And Scocco almost had a dream start, confidently shaping to shoot after receiving a knock-down from Borini and blasting a bullet of a shot into the side-netting.
But there was no way back for Sunderland, as Spurs produced the killer goal 12 minutes from time – Eriksen receiving possession and guiding a low left-footed shot beyond Mannone's outstretched fingertips from 20 yards.
The hosts, who moved back into the top six with the win, added gloss to the scoreline in the 86th minute with Adebayor notching his second goal of the game, rolling the ball into the empty net despite claims for an offside after Mannone had blocked Kane's shot.
And a fifth goal arrived in the second minute of stoppage time - Adebayor guiding the ball into the path of sub Sigurdsson, who blasted home from close range.
- Bezerra Maciel Júnior (Veljkovic)
- Lennon (Townsend)
- Chadli (Sigurdsson)
- Cuéllar (Gardner)
- Alonso Yellow
- Cattermole (Scocco) Yellow
- Guimarães Cordeiro